Season 1, Episode 1: Space Pilot 3000
Heads that I could see (not including presidents): Gillian Anderson, David Duchovny, Liz Taylor, Dennis Rodman, Matt Groening, Barbra Streisand... and, of course, Leonard Nimoy and Dick Clark.
When this episode first aired, a man being sucked into a transportation tube announced his destination as JFK Jr. airport. Since the death of JFK Jr., the episode has been edited so that the man's destination is Radio City Mutant Hall.
"Please select mode of death: quick and painless or slow and horrible." -Automated voice
"Yeah, I'd like to place a collect call." -Fry
"You have selected slow and horrible." -Automated voice
"Great choice." -Bender
"Why would a robot need to drink?" -Fry
"I don't need to drink, I can quit anytime I want." -Bender
"Good lord. What is this?" -Fry
"It's the decaying ruins of old New York. Welcome home, pal!" -Bender
Written by David X. Cohen and Matt Groening, Directed by Rich Moore, Gregg Vanzo
Special Appearances by Dick Clark, Leonard Nimoy. Guest starring Tress MacNeille, Dave Herman, Kath Soucie.